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CYCLIC NUCLEOTIDE PHOSPHODIESTERASES, TYPE 6
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DeCS
Descriptor
English
:
Cyclic Nucleotide Phosphodiesterases, Type 6
Descriptor
Spanish
:
Fosfodiesterasas de Nucleótidos Cíclicos Tipo 6
Descriptor
Portuguese
:
Nucleotídeo Cíclico Fosfodiesterase do Tipo 6
Tree Number:
D08.811.277.352.640.150.600
D08.811.277.352.640.155.750
D12.644.360.008.600
D12.644.360.009.750
D12.776.476.008.600
D12.776.476.009.750
Definition
English
:
A cyclic nucleotide phosphodiesterase subfamily that is highly specific for
CYCLIC GMP
. It is found predominantly in the outer segment
PHOTORECEPTOR CELLS
of the
RETINA
. It is comprised of two catalytic subunits, referred to as alpha and beta, that form a dimer. In addition two regulatory subunits, referred to as gamma and delta, modulate the activity and localization of the enzyme.
History Note
English
:
2008(2001)
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
CT
contraindications
DF
deficiency
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
SE
secretion
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
52681
Unique Identifier:
D054707
Occurrence in VHL
:
Similar:
DeCS
CID-10
SciELO
LILACS
LIS